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Laboratory of Drug Discovery

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Discovery and Binding Mechanism of Pyrazoloisoquinoline-Based Novel β-Arrestin Inverse Agonists of the Kappa-Opioid Receptor

Discovery and Binding Mechanism of Pyrazoloisoquinoline-Based Novel β-Arrestin Inverse Agonists of the Kappa-Opioid Receptor
  • AuthorJae-Hoon Jung, In Hee Jang, Moon Young Yang, Sunhong Kim, Soo-Kyung Kim, William A Goddard III, Yong-Chul Kim
  • Year2023
  • SourceJournal of Medicinal Chemistry

Discovery of pyrazole-1-carboxamide derivatives as novel Gi-biased μ-opioid receptor agonists
  • AuthorJae-Hoon Jung, In Hee Jang, Yeo Ok Kim, Sunhong Kim, Myung Ha Yoon, Yong-Chul Kim
  • Year2022
  • SourceDrug Development Research

Discovery of indirubin-3′-aminooxy-acetamide derivatives as potent and selective FLT3/D835Y mutant kinase inhibitors for acute myeloid leukemia
  • AuthorJe-Heon Lee, Ji Eun Shin, WooChan Kim, Pyeonghwa Jeong, Myung Jin Kim, Su Jin Oh, Hyo Jeong Lee, Hyun Woo Park, Sun-Young Han, Yong-Chul Kim
  • Year2022
  • SourceEuropean Journal of Medicinal Chemistry
AI-based prediction of new binding site and virtual screening for the discovery of novel P2X3 receptor antagonists

AI-based prediction of new binding site and virtual screening for the discovery of novel P2X3 receptor antagonists
  • AuthorKoon Mook Kang, Ingoo Lee, Hojung Nam, Yong-Chul Kim
  • Year2022
  • SourceEuropean Journal of Medicinal Chemistry

Kinetic profiling and functional characterization of 8-phenylxanthine derivatives as A2B adenosine receptor antagonists
  • AuthorAnna Vlachodimou, Henk de Vries, Milena Pasoli, Miranda Goudswaard, Soon-Ai Kim, Yong-Chul Kim, Mirko Scortichini, Melissa Marshall, Joel Linden, Laura H Heitman, Kenneth A Jacobson, Adriaan P IJzerman
  • Year2022
  • SourceBiochemical Pharmacology

Discovery of 5-methyl-1H-benzo [d] imidazole derivatives as novel P2X3 Receptor Antagonists
  • AuthorJinsu Bae, Koon Mook Kang, Yong-Chul Kim
  • Year2022
  • SourceBioorganic & Medicinal Chemistry Letters

Discovery of substituted indole derivatives as allosteric inhibitors of m6A‐RNA methyltransferase, METTL3‐14 complex
  • AuthorJe-Heon Lee, Subin Kim, Mi Sun Jin, Yong‐Chul Kim
  • Year2022
  • SourceDrug Development Research

Eltrombopag as an Allosteric Inhibitor of the METTL3-14 Complex Affecting the m6A Methylation of RNA in Acute Myeloid Leukemia Cells
  • AuthorJe-Heon Lee, Namjeong Choi, Subin Kim, Mi Sun Jin, Haihong Shen, Yong-Chul Kim
  • Year2022
  • SourcePharmaceuticals

Development of Dibenzothiazepine Derivatives as Multifunctional Compounds for Neuropathic Pain
  • AuthorYoung-Hwan Jung, Yeo Ok Kim, Koon Mook Kang, Hyung Gon Lee, Borum Son, Xuehao Han, Eunseok Oh, Siwon Kim, Seon Hee Seo, Jong-Hyun Park, Ki Duk Park, Woong Mo Kim, Myung Ha Yoon, Yong-Chul Kim
  • Year2022
  • SourcePharmaceuticals

Involvement of endoplasmic reticulum stress and cell death by synthesized Pa-PDT in oral squamous cell carcinoma cells
  • AuthorHyo-Eun Yoon, Mee-Young Ahn, Yong-Chul Kim, Jung-Hoon Yoon
  • Year2022
  • SourceJournal of Dental Sciences
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