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Osteoarthritis Research Laboratory

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Low-density lipoprotein receptor-related protein 5 governs Wnt-mediated osteoarthritic cartilage destruction
  • Year2014
  • SourceArthritis Res Ther. 2014 Jan 31;16(1):R37.

hnRNP M facilitates exon 7 inclusion of SMN2 pre-mRNA in spinal muscular atrophy by targeting an enhancer on exon 7
  • Year2014
  • SourceBiochim Biophys Acta. 2014;1839(4):306-15.

Hypoxia-inducible factor-2α is an essential catabolic regulator of inflammatory rheumatoid arthritis.
  • Year2014
  • SourcePLoS Biol. 2014 Jun 10;12(6):e1001881.

Regulation of the Catabolic Cascade in Osteoarthritis by the Zinc-ZIP8-MTF1 Axis
  • Year2014
  • SourceCell 156, 730?743, February 13, 2014

NAMPT (visfatin), a direct target of hypoxia-inducible factor-2α, is an essential catabolic regulator of osteoarthritis.
  • Year2013
  • SourceAnn Rheum Dis doi:10.1136/annrheumdis-2013-204355

Dickkopf-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice.
  • Year2012
  • SourceArthritis Rheum. 2012 Aug;64(8):2568-78. doi: 10.1002/art.34481

Misexpression of Dickkopf-1 in endothelial cells, but not in chondrocytes or hypertrophic chondrocytes, causes defects in endochondral ossification.
  • Year2012
  • SourceJ Bone Miner Res. 2012 Mar 9. doi: 10.1002/jbmr.1583.

α-Catenin inhibits β-catenin-T-cell factor/lymphoid enhancing factor transcriptional activity and collagen type II expression in articular chondrocytes through formation of Gli3R.α-catenin.β-catenin ternary complex
  • AuthorRhee J, Ryu JH, Kim JH, Chun CH, Chun JS.
  • Year2012
  • SourceJ Biol Chem. 2012 Apr 6;287(15):11751-60. Epub 2012 Feb 1

Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction.
  • Year2012
  • SourceCell Death Differ. 2012 Mar;19(3):440-50. doi: 10.1038/cdd.2011.111. Epub 2011 Aug 26

Phosphorylation of Ser 21 in Fyn regulates its kinase activity, focal adhesion targeting, and is required for cell migration
  • Year2011
  • SourceJ Cell Physiol. 2011 Jan;226(1):236-47
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