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Laboratory of Drug Discovery

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Isobolographic Analysis of Drug Combinations With Intrathecal BRL52537 (κ-Opioid Agonist), Pregabalin (Calcium Channel Modulator), AF 353 (P2X3 Receptor Antagonist), and A804598 (P2X7 Receptor Antagonist) in Neuropathic Rats
  • AuthorYoung-Hwan Jung, Yeo Ok Kim, Jung Hyun Han, Yong-Chul Kim, Myung Ha Yoon
  • Year2017/8/1
  • SourceAnesthesia & Analgesia

Discovery of potent antiallodynic agents for neuropathic pain targeting P2X3 receptors
  • AuthorYoung-Hwan Jung, Yeo Ok Kim, Hai Lin, Joong-Heui Cho, Jin-Hee Park, So-Deok Lee, Jinsu Bae, Koon Mook Kang, Yoon-Gyoon Kim, Ae Nim Pae, Hyojin Ko, Chul-Seung Park, Myung Ha Yoon, Yong-Chul Kim
  • Year2017/4/6
  • SourceACS chemical neuroscience

Characterization of the indirubin derivative LDD970 as a small molecule aurora kinase a inhibitor in human colorectal cancer cells
  • AuthorKaryn Muzinga Ndolo, Kyeong Ryang Park, Hyo Jeong Lee, Kyoung Bin Yoon, Yong-Chul Kim, Sun-Young Han
  • Year2017/4/1
  • SourceImmune network

ENOblock, a unique small molecule inhibitor of the non-glycolytic functions of enolase, alleviates the symptoms of type 2 diabetes
  • AuthorHaaglim Cho, JungIn Um, Ji-Hyung Lee, Woong-Hee Kim, Wan Seok Kang, So Hun Kim, Hyung-Ho Ha, Yong-Chul Kim, Young-Keun Ahn, Da-Woon Jung, Darren R Williams
  • Year2017/3/8
  • SourceScientific reports

P2X7 receptor antagonists: a patent review (2010–2015)
  • AuthorJin-Hee Park, Yong-Chul Kim
  • Year2017/3/4
  • SourceExpert opinion on therapeutic patents

Escape from adamantane: scaffold optimization of novel P2X7 antagonists featuring complex polycycles
  • AuthorMarta Barniol-Xicota, Seung-Hwa Kwak, So-Deok Lee, Emily Caseley, Elena Valverde, Lin-Hua Jiang, Yong-Chul Kim, Santiago Vázquez
  • Year2017/2/15
  • SourceBioorganic & medicinal chemistry letters

Novel inhibitors of lysine (K)-specific Demethylase 4A with anticancer activity
  • AuthorHyo Jeong Lee, Bo-Kyoung Kim, Kyoung Bin Yoon, Yong-Chul Kim, Sun-Young Han
  • Year2017/12/1
  • SourceInvestigational new drugs

Intratumoral photodynamic therapy with newly synthesized Pheophorbide a in murine oral cancer
  • AuthorMee-Young Ahn, Hyo-Eun Yoon, Seong-Yong Moon, Yong-Chul Kim, Jung-Hoon Yoon
  • Year2017/1/26
  • SourceOncology Research Featuring Preclinical and Clinical Cancer Therapeutics

2, 3, 4-Trihydroxybenzyl-hydrazide analogues as novel potent coxsackievirus B3 3C protease inhibitors
  • AuthorBo-Kyoung Kim, Hyojin Ko, Eun-Seok Jeon, Eun-Seon Ju, Lak Shin Jeong, Yong-Chul Kim
  • Year2016/9/14
  • SourceEuropean journal of medicinal chemistry

Potent suppressive effects of 1-piperidinylimidazole based novel P2X7 receptor antagonists on cancer cell migration and invasion
  • AuthorJin-Hee Park, Darren R Williams, Ji-Hyung Lee, So-Deok Lee, Je-Heon Lee, Hyojin Ko, Ga-Eun Lee, Sujin Kim, Jeong-Min Lee, Aliaa Abdelrahman, Christa E Müller, Da-Woon Jung, Yong-Chul Kim
  • Year2016/8/9
  • SourceJournal of medicinal chemistry
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